I am trying to understand results from GWAS studies, and I have this question:
Why can't GWAS studies speculate about what kind of consequence would the specific SNP have? As they information about the precise position on the genome + which base changes, I thought studies would speculate if the SNP in question causes a silent/missense/nonsense mutation, but they apparently do not (at least those I have read).
I guess some information is missing or uncertain to speculate about that... What is it? I was thinking maybe which frame is read?