Filtering using TLOD score in MuTect2?

Question

[Sharon]

Hi Every one

I have more than 40 K somatic mutation per tumor sample we have. I think we have lots of false positives because we used a panel of normal (10 samples) but we don't have a matched normal-tumor that help filtering germline better.

Would being very stringent in the TLOD score a reasonable filtering step?

Thanks