Question: (Closed) The shape of my ... enrichment profile !?
gravatar for gregoire.destreel
14 months ago by
gregoire.destreel10 wrote:

Dear users,

Does someone can explain the curve shape of GSEA analysis enrichement profile? As control of my GSEA analysis with PreRanked data set following Log2FoldChange, I did the same analysis but with Log2FoldChange randomly attributed to genes of my data set. The consequence is that, in the interrogated genes sets, I have systematically lower ES values and much higher FDR (>25%) in the control GSEA analysis which is really consistent.

However, the curve shape of the enrichment profile is always (in all genes sets) with the peak offset to the left of the graph.. and this also for my control GSEA analysis... I cannot understand the basis of this, and why in the control one it does not acquire completely random shape (with peak in the middle for ex.)

Can you help me to make up my mind with this?

Thank you !

gsea rna-seq broad institute • 214 views
ADD COMMENTlink modified 14 months ago by WouterDeCoster42k • written 14 months ago by gregoire.destreel10

Hello gregoire.destreel!

Questions similar to yours can already be found at:

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ADD REPLYlink written 14 months ago by WouterDeCoster42k
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