Question: Whether to include reference genome in PCA for association analysis?
0
gravatar for Phoenix Mu
16 months ago by
Phoenix Mu20
Phoenix Mu20 wrote:

When doing QC for GWAS, genotype from a reference panel like 1000 Genomes is typically used to calculate PCA together with our own data to find individuals with unmatched population ancestry.

My question is if I want to calculate PCs used for adjusting population admixture in my GWAS, do I also need to include a reference panel in my PCA?

Thanks

pca gwas • 456 views
ADD COMMENTlink modified 16 months ago by zx87549.1k • written 16 months ago by Phoenix Mu20
1
gravatar for zx8754
16 months ago by
zx87549.1k
London
zx87549.1k wrote:

Use reference panel to get PCs, this step is useful to filter out outlier samples. Then exclude outlier samples and reference samples, and re-run PCA. These are the PCs we want to use for analysis.

See this paper for more info:

ADD COMMENTlink written 16 months ago by zx87549.1k
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