Question: Databases and Variant Tools for Cancer Genes
0
gravatar for ojelizodun
10 weeks ago by
ojelizodun0
ojelizodun0 wrote:

I am lost on how to get mutated variants of some cancer genes like BRCA1, BRCA2, BRIP1, PALB2, etc. Please, which database or tool should I explore? Thank you.

ADD COMMENTlink written 10 weeks ago by ojelizodun0
1

It is unclear which data you have and what you aim to achieve, please elaborate.

ADD REPLYlink written 10 weeks ago by WouterDeCoster36k

Alright. I only intend to know the available variants of each of these genes.I have accessed the main DNA sequences, but accomplishing the task of knowing their mutated variants is the help I need.
Thank you.

ADD REPLYlink written 10 weeks ago by ojelizodun0

Which "main DNA sequences"? What does that mean? You have to be more specific. Please elaborate. What are "the available variants"?

ADD REPLYlink written 10 weeks ago by WouterDeCoster36k
3
gravatar for Kevin Blighe
10 weeks ago by
Kevin Blighe37k
Republic of Ireland
Kevin Blighe37k wrote:

...and remember that there is a difference between a somatic mutation and an inherited germline variant that increases your risk of cancer over your lifetime. Genes like the ones that you've listed are required for normal functioning of cells (BRCA1, BRCA2, are for DNA double-strand break repair) - they are associated with increased lifetime risk of cancer. Take a look at this previous answer: A: What's the difference between GWAS Catalog and COSMIC database ?

ADD COMMENTlink modified 10 weeks ago • written 10 weeks ago by Kevin Blighe37k

Wahoo! These two databases should help, especially COSMIC. I will explore them. Thank you.

ADD REPLYlink written 10 weeks ago by ojelizodun0
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