GWAS Make bed file from fam and bim and Polygenic Risk Score calculation

Question

[landscape95]

Hi everyone, previously I had a set of bed/bim/fam file in Plink format for GWAS, now I have separate a set of Discovery and Target Samples for Polygenic Risk Score analysis. However, if I select individuals from the .fam file, the bed file will not be suitable for this set of bed/bim/fam file anymore. Does anyone know how to create a new bed file from bim and fam file or am I doing the right way?

Your help is really appreciated!

[zx8754]

I don't understand the question. Please clarify. If this is about Plink formats, then:

• bim is a map file for variants, like chr, pos...
• fam is a phenotype file, FID, IID, sex, status...
• bed is a binary genotype file, which is completely useless without having related above bim and fam files.

We cannot create new bed file from bim and fam.

[landscape95]

thank you, that's about Plink format.

[landscape95]

I have another question, in this case how can I make a Target sample data set, I already had the id of the Discovery and Target set from the total samples which I have in the set of bed/bim/fam file? Thank you very much!