Question: Survival analysis based on gene expression
0
gravatar for archie
17 months ago by
archie90
India
archie90 wrote:

Hello everyone I performed the gene expression based survival analysis and selected genes (1700 genes) with Log-Rank test p value < 0.05. I have list of LogRank" "HR" "HRlower" "HRupper" associated to each gene. But , I want to classify genelist into further two gene lists: high expression pattern correlated with poor survival and low expression pattern correlated with poor survival as mentioned in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630377/ . I am new in area of survival analysis. I will appreciate all suggestion.

Thanks in advance

survival gene expression • 1.1k views
ADD COMMENTlink modified 16 months ago by Biostar ♦♦ 20 • written 17 months ago by archie90

You may want to go into further detail about how you have performed the current survival analysis. Like, literally, show the code and describe the dataset that you used. If you simply want to classify the genes into high and low expression, then just take, for example, the upper- and lower- tertiles or quartiles of the expression range.

ADD REPLYlink written 17 months ago by Kevin Blighe61k

You can follow this tutorial. Here maxstat R package is used to classify patients into high and low groups.

ADD REPLYlink written 17 months ago by newbie70
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