Change ALT field in VCF
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2.2 years ago
biosol ▴ 150

Hi all,

I have 2 vcf files for the same positions but with different individuals which I would like to merge. However, in one of the files some of my variants have a . in the ALT field, which I would like to replace by the corresponding allele. I've tried to obtain those alternatives alleles from my other vcf which looks apparently correct. I'm using the following command of vcftools:

plink --vcf my.vcf --const-fid 0 --a1-allele ALT.txt 5 3 '#' --recode --out myfile.mod.vcf


ALT.txt contains two columns: SNPID and ALTfield of my other vcf file (I've tried both with and without header). Still, the program says: Error: Fewer tokens than expected on line 1 of --a1-allele file.

I don't know what I'm doing wrong so I would appreciate it if anyone sees something that I'm not seeing or if anyone recommends other tools. Thank you very much in advanced :)

vcf snps gwas • 948 views
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what is the output of

 head ALT.txt


and

file ALT.txt

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head ALT.txt
rs10032042      G
rs10174691      C
rs10221923      G
rs10223644      G
rs1028771       C
rs10305678      G
rs10404081      G
rs10421281      C
rs1042478       G
rs10459252      C

file ALT.txt
file ALT.txt: ASCII text