Question: how to get Z-score without normal samples as control group in nipt(Non-invasive prenatal testing)
0
gravatar for Leon
23 months ago by
Leon120
Leon120 wrote:

Hi, i have a cfDNA sequencing data of a pregnant woman, i want to test the existence of trisomy or not. However, it is not possible to get Z-score value of the sample without a set of normal samples as control group. I think this will be a very useful question for people like me meeting such question. So anyone can give me a alterative method? Thanks!

next-gen • 468 views
ADD COMMENTlink written 23 months ago by Leon120

Maybe I do not understand your question but a z-score is defined as z = (x - x̄ )/ s where x̄ is the sample mean and s the standard deviation. Could you maybe use cfDNA of the other chromosomes as control ? You should describe a little bit more your problem.

ADD REPLYlink written 23 months ago by Nicolas Rosewick9.3k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1767 users visited in the last hour
_