I am fairly novice Bioinformatician. I need some help and suggestions on tools that I can use to subset my annotated vcf file using specific criteria. The criteria are: (i) Coding and Splice site variants (ii) CADD > 10 if nonsynonymous SNPs (iii) AA change: Nonsense (iv) Absent in Exac database (v) Frequency is KAVIAR: 6.4E -06. I am working on the python code because I couldn't find any tool that serves my need. So far I have tried GATK's varianttotable, variantfiltration, bcftool, vcftool. I would like to know if there are any tools or tool out there which can parse the INFO column of vcf file and help to filter/subset the file based on selected criteria. Thank you in advance for your help!