Effect prediction of chromosome break
1
0
Entering edit mode
22 months ago

Hello guys,

I really need help with one question. In our lab we found a new chromosome break, in our case two genes rearrange within the same chromosome. This was discovered using sanger sequencing and FISH. Since our rearrange is new in literature I need to predict the effect of this change, so I was wondering if you know any software that do this prediction with this type of data! I normally use softwares and pipelines to predict the effect of point mutations, but I never saw anything to do this with gene and chromosome break.

I appreciate any help!

Thanks

Thaise

chromosome • 344 views
ADD COMMENT
1
Entering edit mode
22 months ago

Well, what is the observed phenotype of the patient? - that can help to guide you.

I am not aware of anything that can specifically predict the effects of a chromosomal 'breakage'; however, you may consider addressing this question by researching the function of the genes that are lost as a result of the breakage. You should not have to in silico predict this. Some intensive literature review and researching of the lost genes should suffice.

Kevin

ADD COMMENT

Login before adding your answer.

Traffic: 2000 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6