Question: Effect prediction of chromosome break
gravatar for thaisenayane
10 months ago by
thaisenayane0 wrote:

Hello guys,

I really need help with one question. In our lab we found a new chromosome break, in our case two genes rearrange within the same chromosome. This was discovered using sanger sequencing and FISH. Since our rearrange is new in literature I need to predict the effect of this change, so I was wondering if you know any software that do this prediction with this type of data! I normally use softwares and pipelines to predict the effect of point mutations, but I never saw anything to do this with gene and chromosome break.

I appreciate any help!



chromosome • 201 views
ADD COMMENTlink written 10 months ago by thaisenayane0
gravatar for Kevin Blighe
10 months ago by
Kevin Blighe63k
Kevin Blighe63k wrote:

Well, what is the observed phenotype of the patient? - that can help to guide you.

I am not aware of anything that can specifically predict the effects of a chromosomal 'breakage'; however, you may consider addressing this question by researching the function of the genes that are lost as a result of the breakage. You should not have to in silico predict this. Some intensive literature review and researching of the lost genes should suffice.


ADD COMMENTlink written 10 months ago by Kevin Blighe63k
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