I do cox analysis(100+ genes Univariate) with
survival package, then
p.adjust and filter by
p.adj < 0.05.
First I use origin FPKM-UQ value from gdc, I get a few genes but all HR value very close to 1(1.000000xxxx). Then I use
log2(FPKM + 1) get more genes and HR value seems normal(discrete from 1).
This seems I should use log2 FPKM value. But I don't figure out why origin FPKM value will let HR value near 1.