Question: hmmsearch against pfam database
0
gravatar for aatirarajendran
9 months ago by
aatirarajendran0 wrote:

how to analyse hmmsearch result against pfam database? i got more than one domain result, how to identify which one is best one?what is the reason for this multiple domain result?

rna-seq • 295 views
ADD COMMENTlink modified 9 months ago by h.mon30k • written 9 months ago by aatirarajendran0

What does this have to do with the tag rna-seq?

ADD REPLYlink written 9 months ago by Joe17k
1
gravatar for h.mon
9 months ago by
h.mon30k
Brazil
h.mon30k wrote:

what is the reason for this multiple domain result?

Because proteins can have multiple domains, and proteins from different families can share domains. The Wikipedia page on protein domains is a good introduction, and you will find there an extensive literature review.

how to identify which one is best one?

As proteins can have multiple domains, there may be no "best" domain. Of course, one has to filter false-positives, but this doesn't mean one will end up with just one domain per protein.

ADD COMMENTlink written 9 months ago by h.mon30k
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