Question

Haplotype association in case control studies

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4.2 years ago

mel22 ▴ 100

Hi , As a part of my analyses, I used Haplotype association test from Beagle 3. The results were interstion, but the problem that if I want to take into accotunt cofactors (sex,age,BMI ...) I had to use the output fro beagle in R. This step was not clear at all for me, so does any one have an experience with this or knows an aletrnative ?!

Thank you very much

SNP case-control Beagle3 • 989 views

ADD COMMENT • link updated 4.2 years ago by Kevin Blighe 87k • written 4.2 years ago by mel22 ▴ 100

score 1 · Answer 1 · 2020-02-14

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4.2 years ago

Kevin Blighe 87k

If you want to adjust for covariates (sex, age, BMI, et cetera), then you need to conduct a logistic regression analysis using the output of the haplotype analysis.

Kevin

ADD COMMENT • link 4.2 years ago by Kevin Blighe 87k

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Hi Kevin, thanks for your reply, I understand that I have to use Beagle out put but how ? Do you have an experience with this ?

Thank you

ADD REPLY • link 4.2 years ago by mel22 ▴ 100

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What data do you have right now? - please paste some examples

ADD REPLY • link 4.2 years ago by Kevin Blighe 87k