Entering edit mode
2.9 years ago
geethus2009 • 0
which is better pairwise sequence alignment or multiple sequence alignment to generate 3 d of protein? how to get template structure of sequence which provide more sequence similarity? I have come across some web server that offers 3d structure prediction? is it possible to get the source code of their work?
Can you help me to implement a 3-d protein structure prediction work? using python 3.7 windows
Thank you so much for your valuable support and suggests in advance
No - this is an enormously complicated task, and python would be far too slow anyway. Stick to using well-published and utilised software tools like Phyre/ITASSER/MODELLER.
Alignment is just one tiny part of the whole process of reference guided modelling. Any good modelling tool will handle the template selection for you anyway. It doesn't really make sense to ask which of pairwise or MSA is 'better' in this context since they serve different purposes.
For some, yes. When you download a local install of ITASSER, pretty much all the code (other than perhaps a few C binaries) is available. I'm not sure about the other tools as I don't tend to use those.