If i define a list of genes by applying some machine learning or any regularization methods, if we say i get 200 genes. From those 200 genes, i find 50 genes existed in the literature, or even by applying cross validation and define that those genes are significant, what about the others and how i can validate them or considered them as new genes in my study ? So my main question is how to define newly discovered genes from my this list or how to judge that these genes are new genes obtained in my study? Do i need any statistical tests or any method ??
I appreciate any help please!