CNV callers for WES data

Question

[patelk26]

Hello,

I want to call somatic CNVs for Whole Exome Sequencing data. These are tumor samples, with no normal/control samples available. I read this article and tried a couple of tools like ADTEX and ExomeCNV, however they require normal samples to be provided as well. I cannot run with just tumor samples.

I would really appreciate some recommendations for tools I can try.

Thank you.

[linouhao]

not a good choice, cnvkit can do this, but the result is not good