Question: How can I normalize RPKM data from TCGA (pan-cancer analysis)?
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gravatar for lenC_biotecLover
4 months ago by
lenC_biotecLover0 wrote:

I have a matrix with different miRNA RPKM values downloaded from TCGA, relatively to different TCGA projects (BRCA, LAML, LUAD ecc.) columns: TCGA-barcodes, rows: miRNa identifier.

In order to perform a machine learning analysis how can I normalize all this data between the patients in my matrix? I searched all around the web but I couldn't find any answer.

I'm really a novice in bioinformatics and computational biology, and any advice is strongly appreciated. Thank you very much.

ADD COMMENTlink modified 4 months ago • written 4 months ago by lenC_biotecLover0
0
gravatar for swbarnes2
4 months ago by
swbarnes29.2k
United States
swbarnes29.2k wrote:

RPKM already is normalized.

ADD COMMENTlink written 4 months ago by swbarnes29.2k

I know, but I meant between the patients, considering that I've data from different projects

ADD REPLYlink modified 4 months ago • written 4 months ago by lenC_biotecLover0
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