I have a matrix with different miRNA RPKM values downloaded from TCGA, relatively to different TCGA projects (BRCA, LAML, LUAD ecc.) columns: TCGA-barcodes, rows: miRNa identifier.
In order to perform a machine learning analysis how can I normalize all this data between the patients in my matrix? I searched all around the web but I couldn't find any answer.
I'm really a novice in bioinformatics and computational biology, and any advice is strongly appreciated. Thank you very much.