Annotate multiple sample vcf files at once using ANNOVAR

Question

[Dhara Awasthi]

Hey everyone! I have obtained the 1092 individual sample vcf files after splitting the ALL.chr3.phase1_release_v3.20101123.snps_indels_svs.genotypes.HG00096.vcf.gz from 1000g .

I have to further process and annotate them using ANNOVAR. How can I do it at once? Do I have to take care of the version of the database while downloading?

PLEASE HELP!!!

Answer 1

[Kevin Blighe]

Dear dharaawasthi,

The Quick Start is quite helpful:

• https://annovar.openbioinformatics.org/en/latest/user-guide/startup/

Then, specific databases are listed here:

• https://annovar.openbioinformatics.org/en/latest/user-guide/filter/#overview

Apologies if you have already read through these web-pages.

kevin