Tool: Chance: Comprehensive Software For Quality Control And Validation Of Chip-Seq Data
gravatar for Aaron Diaz
4.3 years ago by
Aaron Diaz20
San Francisco, CA
Aaron Diaz20 wrote:

Hi, We at UCSF have recently developed a software tool for ChIP-seq quality control and protocol optimization called CHANCE, which appears in the current special issue of Genome Biology:

CHANCE has a graphical interface and doesn't require any knowledge of programming or statistics. The CHANCE program as well as the source code can be downloaded from:

thanks, Aaron Diaz Inst. for Human Genetics, UCSF

chip-seq quality next-gen qc tool • 2.3k views
ADD COMMENTlink modified 6 months ago by paul.e.gradie50 • written 4.3 years ago by Aaron Diaz20
gravatar for paul.e.gradie
6 months ago by
Australia/Melbourne/University of Melbourne
paul.e.gradie50 wrote:

Wow - no updates to this?

Who is going to use this if it can't accommodate mm10?

I'll put an alternative out there: DeepTools.

These guys did a fantastic job of coding up a suite of tools for assessing sequencing results. Most importantly for ChIP, it provides the Plot_Fingerprint tool for using SES (signal extraction scaling) to asses enrichment strength. The original paper that both CHANCE and DeepTools based this on can be found here:

Its clean, beautiful, and the source code is written in Python (so if you're like me and looking for a large Python project to digest, this is your ticket!)

Cheers, Paul

ADD COMMENTlink written 6 months ago by paul.e.gradie50
gravatar for André Rendeiro
3.0 years ago by
Vienna, Austria
André Rendeiro50 wrote:

I heard about CHANCE recently and just for curiosity would like to run it on my data which is from unsuported organisms.

I can't find any manual reference on how to add a custom build to use in CHANCE.

Adding annotation for a custom genome shouldn't be too difficult, unless the currently supported builds (hg18, hg19, mm9) are for some reason hard-coded in the CHANCE code. Before I start looking more deeply into this, has anyone tried to do this?

ADD COMMENTlink written 3.0 years ago by André Rendeiro50

Hi André, did you manage to run it on a custom build? 

ADD REPLYlink written 20 months ago by sinha0
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