Mapping Chicken Protein Names To Corresponding Gene Names
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8.4 years ago
mimA ▴ 30

Hello,

I have a long list of transcription factor protein names and IDs for chicken. I want to get the corresponding gene names and gene IDs. How can I do that in a quick way as it is tedious to look for each protein separately. Can it be done in R?

The file looks like this:

Ensembl Protein ID    Description
ENSGALP00000000063    cold shock domain containing C2, RNA binding [Source:HGNC Symbol;Acc:30359]
ENSGALP00000000227    myogenin (myogenic factor 4)  [Source:RefSeq peptide;Acc:NP_989515]
ENSGALP00000000232    Kruppel-like factor 3 (basic) [Source:HGNC Symbol;Acc:16516]
ENSGALP00000000311    Sp2 transcription factor [Source:HGNC Symbol;Acc:11207]
ENSGALP00000000406    Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:E1C668]

Similarly I have Affymetrix gene IDs for chicken that I want to map to gene names and it looks like this:

Gga.4558.2.S1_s_at
GgaAffx.21351.1.S1_s_at
Gga.11474.1.S1_a_at
GgaAffx.21384.1.S1_s_at
Gga.17952.1.S1_at
Gga.7798.1.S1_at
Gga.11798.1.S1_s_at
GgaAffx.12750.1.S1_s_at
GgaAffx.7263.1.S1_at
Gga.9266.1.S1_a_at
Gga.752.1.S1_at
Gga.16740.1.S1_at
GgaAffx.10527.1.S1_at
Gga.19004.1.S1_at

How can I map these to genes names in R? Many thanks.

r • 2.1k views
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Can you show us, how the data looks like, just the head.

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And edit what you posted; it needs spaces.

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8.4 years ago
Ben ★ 2.0k

You haven't said which type of protein IDs you have but I'll assume they're refseq / ensembl / entrez or similar common IDs.

It can be done in R, for example using the biomaRt bioconductor package, alternatively you could strip your list of IDs and use them as a filter in ensembl biomart directly, you can then select which identifiers you require as results.

Similarly, biomart central has an ID conversion tool which will go from protein -> gene ID.

Edit: Now you've added your IDs as examples, the most straightforward method of conversion (depending on how many you have) is to use biomart's gene ID conversion tool

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