Hi,

I am looking for a way to simulate a phenotype associated with several loci starting from an existing genotype data in R. Is it possible to do this simulation directly in R? I am not a statistician and I cannot find a good reference to follow for calculations that can help me simulate an association with several loci and several causal SNPs, explaining a certain percentage of variance and with a certain heritability. If anybody has some idea about how to do this type of calculation directly in R I would appreciate any help.

Thank you in advance. James

Thank you Josh. It looks like all of the softwares either require that either the genotype data be generated with the same software or that the genotype data be manipulated as if I was using the same software. I thought there was a simpler way in R with either some commands or a R package. If there is indeed a way to specify commands in R or an R package for this please someone let me know, otherwise it looks like I would need to use a software like the ones Josh suggested.

Thank you