I saw a few question people on twitter asking why the Japanese government might want to distribute iodine tablets to protect against radiation from the damaged Fukushima nuclear plants. Part of the answer to that question is that iodine (both radioactive and normal) are actively concentrated in the thyroid because of thyroxine production. The active thyroid hormone products contain either 3 triiodothyronine (T3) or 4 thyroxine (T4) iodine atoms.
It would be good to have an easy to understand visualization of the thyroxine production pathway to explain this better. If that would also include the relevant genes active in transport and synthesis, it could furthermore be a start to understand or evaluate risks better. It could for instance help to ask the question whether Japanese or older people would be relatively (in)sensitive depending on the relative expression of these genes or possible variants in them.
Currently we have the thyroxine production pathway as part of the Reactome pathway "Metabolism of amino acids and derivatives" that is also available for community curation as WikiPathways pathway WP1847. But that does not really give a clear overview of this specific process. Does anyone know of a better, more explanatory visualization of that same pathway which could be used as the start of a more intuitive pathway at WikiPathways?
Thanks to help from some Biostar users we now have a start of a real pathway for thyroxine production, it still needs a lot of work, but there is some interesting info in it.