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Question: Inverse Normal Transformation Of A Quantitative Trait In Gwas
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gravatar for snp_cook12
6.0 years ago by
snp_cook12 • 0
United States
snp_cook12 • 0 wrote:

hello, I have a question, how do you inverse normally transform a quantitative trait for genetic association studies?
gwas association • 9.8k views
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modified 22 months ago by zju.whw • 40 • written 6.0 years ago by snp_cook12 • 0
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gravatar for Devon Ryan
6.0 years ago by
Devon Ryan ♦ 91k
Freiburg, Germany
Devon Ryan ♦ 91k wrote:

Here's a nice paper on Pubmed Central discussing issues surrounding inverse normal transforms. In general, the idea is to match the normalized rank of the trait to a quantile in a normal distribution. Have a look at equation 1 in the paper I linked to.
ADD COMMENT • link written 6.0 years ago by Devon Ryan ♦ 91k
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gravatar for zju.whw
22 months ago by
zju.whw • 40
China
zju.whw • 40 wrote:

I think the paper mentioned by Devon Ryan worths to read.

To do INT(inverse-normal transformation), you can use the R code below:

qnorm((rank(x,na.last="keep")-0.5)/sum(!is.na(x)))

See the supplement of this paper - Yang et al. Nature 2012.
ADD COMMENT • link written 22 months ago by zju.whw • 40
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