Question: Correlation Between Alleles

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thjnant •

**90**wrote:Hello,

I am currently studying on F statistics. The problem that has puzzled me is that concept of correlation between alleles or gametes. I know the meaning of correlation between two random variables but what does it really mean when we talk about it in the context of fst?

A good place to look, and Giovanni knows something about it ;-)

Wright's Fst and Weir & Cockerham's Fst estimator - simple explanation of the difference

2.4kwhat do you mean, exactly? Correlation between alleles of neighbor loci? Can you give some more context? Thanks

26kI am using Wright's original definition of F statistics where he mentions:

F: the correlation of genes within individuals theta: the correlation of genes of different individuals in the same population f: the correlation of genes within individuals within populations

The concept of correlation is vague for me here.

90Maybe you want to know about linkage disequilibrium, which is an association between 2 or more alleles: https://en.wikipedia.org/wiki/Linkage_disequilibrium

To quote from that page: "...linkage disequilibrium is the occurrence of some combinations of alleles or genetic markers in a population more often or less often than would be expected from a random formation of haplotypes from alleles based on their frequencies...

The amount of linkage disequilibrium depends on the difference between observed allelic frequencies and those expected from a homogenous, randomly distributed model."100