Is it advised to use quantile normalization for scRNA-seq data?
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4 months ago
asifadil ▴ 80

I am currently developing an analytical tool for scRNA-seq data, and I am trying club couple of normalization techniques in that tool. Is it good to keep quantile normalization as an option for the user too?

scRNA-seq quantile normalization single-cell • 331 views
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Sure, why not? You would need to control for dispersion, though. Take a look at limma-voom

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