I want to have an overall visualisation for accessible regions of my interest similar as what plotHeatmap (deeptools) can provide. However, this has become tricky as for this data I just have access to peaks matrix and fragments files from cellranger but not the bam files. I already have tried RegionMatrix + RegionHeatmap available in signac but I have some doubts about the overall outlook. This is because I am comparing cell clusters with relatively large imbalanced sample sizes (500 cells versus 30000 cells) and RegionHeatmap normalizes the fragments counts by total number of cells and the huge heterogeneity within each cluster is not taken into account. So, I barely can see any signal for the cluster with 30000 cells with different sets of regions and I assume this is because of the normalization approach. Is there any other tool/method I can use for this purpose considering the input files I have? Thanks!