What does it means, when 2-direction perturbed pathways are identified in the gage enrichment analysis?
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18 days ago
Assa Yeroslaviz ★ 1.8k

The gage method for enrichment analysis using ENTREZ Ids emphasizes on its capability to test for changes not only for up- and down-regulated pathways, but also for those with a 2-directional change.

I don't understand what this means biologically. Does it mean that the pathway is being significantly deregulated in both directions simultaneously, or that it contains genes that that show a deregulation in both directions?

thanks

r pathway go-enrichment gage • 245 views
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