**280**wrote:

Hi all,

I am trying to understand LOESS normalization. I am pretty sure that the algorithm uses LOESS regression (that is a local regression) to fit data with a curve, and then get the residuals from this curve as normalized data. If I understood well, the curve is fitted on the data on a MAplot.

However, I do not get if LOESS computes a curve for each sample independently or does something different.

Thanks

**3.4k**• written 4.8 years ago by fbrundu •

**280**