Question: Is it possible to predict the physical interacton between two proteins knowing theire sequence?
4.2 years ago by
Pierre Lindenbaum ♦ 120k
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum ♦ 120k wrote:
You'll find many references in pubmed: .eg: http://www.ncbi.nlm.nih.gov/pubmed/15064475
1. Methods Mol Biol. 2004;261:445-68. Computational prediction of protein-protein interactions. Obenauer JC(1), Yaffe MB. Author information: (1)Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. (..) A computational approach to predict protein interactions on a proteome-wide basis would therefore consist of identifying modular domains and sequence motifs from protein primary sequence data, creating sequence specificity-based algorithms to connect a domain in one protein with a motif in another in "interaction space," and then graphically constructing possible interaction networks
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