Question: Is it possible to predict the physical interacton between two proteins knowing theire sequence?
gravatar for dago
5.9 years ago by
dago2.6k wrote:

I have the aa sequences of two proteins.

I was wondering if there is any tool out there that can predict a possible physical interaction among these proteins.



structure prediction protein • 2.2k views
ADD COMMENTlink modified 4.0 years ago by Emre90 • written 5.9 years ago by dago2.6k
gravatar for Pierre Lindenbaum
5.9 years ago by
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum134k wrote:

You'll find many references in pubmed: .eg:


1. Methods Mol Biol. 2004;261:445-68.

Computational prediction of protein-protein interactions.

Obenauer JC(1), Yaffe MB.

Author information: 
(1)Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 

(..) A computational approach to predict protein interactions on a proteome-wide basis
would therefore consist of identifying modular domains and sequence motifs from
protein primary sequence data, creating sequence specificity-based algorithms to 
connect a domain in one protein with a motif in another in "interaction space,"
and then graphically constructing possible interaction networks


ADD COMMENTlink modified 5.9 years ago • written 5.9 years ago by Pierre Lindenbaum134k

Really good paper, I overlooked that

ADD REPLYlink written 5.9 years ago by dago2.6k
gravatar for venu
5.9 years ago by
venu6.8k wrote:

Using CO EVOLUTION is one way of predicting PPI, without use of any structures.

Have a look at

ADD COMMENTlink written 5.9 years ago by venu6.8k
gravatar for Emre
4.0 years ago by
United States
Emre90 wrote:

You might give a try to one of the following web-servers:

ADD COMMENTlink written 4.0 years ago by Emre90
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1451 users visited in the last hour