Question: Is it possible to predict the physical interacton between two proteins knowing theire sequence?
gravatar for dago
4.2 years ago by
dago2.5k wrote:

I have the aa sequences of two proteins.

I was wondering if there is any tool out there that can predict a possible physical interaction among these proteins.



structure prediction protein • 1.8k views
ADD COMMENTlink modified 2.2 years ago by Emre80 • written 4.2 years ago by dago2.5k
gravatar for Pierre Lindenbaum
4.2 years ago by
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum120k wrote:

You'll find many references in pubmed: .eg:


1. Methods Mol Biol. 2004;261:445-68.

Computational prediction of protein-protein interactions.

Obenauer JC(1), Yaffe MB.

Author information: 
(1)Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 

(..) A computational approach to predict protein interactions on a proteome-wide basis
would therefore consist of identifying modular domains and sequence motifs from
protein primary sequence data, creating sequence specificity-based algorithms to 
connect a domain in one protein with a motif in another in "interaction space,"
and then graphically constructing possible interaction networks


ADD COMMENTlink modified 4.2 years ago • written 4.2 years ago by Pierre Lindenbaum120k

Really good paper, I overlooked that

ADD REPLYlink written 4.2 years ago by dago2.5k
gravatar for venu
4.2 years ago by
venu6.1k wrote:

Using CO EVOLUTION is one way of predicting PPI, without use of any structures.

Have a look at

ADD COMMENTlink written 4.2 years ago by venu6.1k
gravatar for Emre
2.2 years ago by
United States
Emre80 wrote:

You might give a try to one of the following web-servers:

ADD COMMENTlink written 2.2 years ago by Emre80
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