Question: vcf not indexing
gravatar for alex
3.3 years ago by
United States
alex170 wrote:

Trying to index vcf file but getting the following

tabix -p vcf dbsnp_138.hg19.vcf.gz
Not a BGZF file: dbsnp_138.hg19.vcf.gz
tbx_index_build failed: dbsnp_138.hg19.vcf.gz


Thoughts on how to proceed?  Thanks!

tabix • 5.1k views
ADD COMMENTlink modified 3.3 years ago by Sean Davis24k • written 3.3 years ago by alex170
gravatar for Sean Davis
3.3 years ago by
Sean Davis24k
National Institutes of Health, Bethesda, MD
Sean Davis24k wrote:

Looks to me like the dbsnp file is not bgzipped?  

gunzip dbsnp_138.hg19.vcf.gz
bgzip dbsnp_138.hg19.vcf
tabix -p vcf dbsnp_138.hg19.vcf.gz
ADD COMMENTlink written 3.3 years ago by Sean Davis24k

@Sean Davis you just saved me a lot of frustration. I found this after a few searches and it worked. THanks

ADD REPLYlink written 15 months ago by jespinoz20
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