Question: Filtering samples or not before normalisation for samples from several groups
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Zhilong Jia • 1.6k wrote:
Is it good or not to filter non-related samples before gene expression normalisation for samples from several groups (for example, A (control), B and C; B and C are a subtype of a disease) because I focus on B Vs A; C Vs A, B Vs C and C+B Vs A. With no filtering, it will be an issue especially when comparing B Vs C, resulting in none differentially expressed genes. Thank you.
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modified 5.0 years ago
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Devon Ryan ♦ 98k
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5.0 years ago by
Zhilong Jia • 1.6k