Question

Tool/algorithm to assess the effect of several mutations

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9.7 years ago

roy.granit ▴ 890

Searching for a tool that could (try to) predict which pathways are predicted to be affected by several mutation co-occurring in a certain tumor.

e.g. mutated PTEN would active the PI3K pathway, and HER2 mutated would also active the MAPK pathway

Thanks!

mutation cancer • 2.7k views

ADD COMMENT • link updated 3.3 years ago by Ram 45k • written 9.7 years ago by roy.granit ▴ 890

Ram · Answer 1 · 2016-02-15

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9.7 years ago

Cyriac Kandoth 6.1k

Here are related tools with varying levels of "ease of use". Good luck!

ADD COMMENT • link updated 3.3 years ago by Ram 45k • written 9.7 years ago by Cyriac Kandoth 6.1k

score 1 · Answer 2 · 2016-02-14

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9.7 years ago

Jean-Karim Heriche 27k

I would look into Boolean network modelling of pathways. There may be cytoscape plug-ins for this.

ADD COMMENT • link 9.7 years ago by Jean-Karim Heriche 27k

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Thanks, good idea

ADD REPLY • link 9.7 years ago by roy.granit ▴ 890

score 1 · Answer 3 · 2018-03-27

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7.6 years ago

Sean Davis 27k

netsig is a new one.

ADD COMMENT • link 7.6 years ago by Sean Davis 27k

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Thanks, will check it out..

ADD REPLY • link 7.6 years ago by roy.granit ▴ 890