Question: getting germline mutations
1
gravatar for alessandrotestori7
3.7 years ago by
alessandrotestori7350 wrote:

Hi, I would like to gather germline mutations of different types of cancer. I am wondering whether these data are publicly available and how I can get them. Thanks, regards. Alessandro

snp • 1.7k views
ADD COMMENTlink modified 3.7 years ago by Chris Miller21k • written 3.7 years ago by alessandrotestori7350
2
gravatar for Chris Miller
3.7 years ago by
Chris Miller21k
Washington University in St. Louis, MO
Chris Miller21k wrote:

The supplemental tables in this paper have quite a bit of information that may be useful: Patterns and functional implications of rare germline variants across 12 cancer types http://www.nature.com/ncomms/2015/151209/ncomms10086/full/ncomms10086.html

If you download the exac dataset (http://exac.broadinstitute.org/), I think you can also subset out the TCGA-derived normals, which would contain potential germline susceptibility genes.

ADD COMMENTlink modified 3.7 years ago • written 3.7 years ago by Chris Miller21k

Thanks, this is exactly what I need. I just hope I can find more similar data publicly available (raw data are also fine).

ADD REPLYlink written 3.7 years ago by alessandrotestori7350
0
gravatar for Vivek
3.7 years ago by
Vivek2.3k
Denmark
Vivek2.3k wrote:

A: Where Can I Find Mutation Databases Specialized In Cancer?

An older post that might be of help.

ADD COMMENTlink written 3.7 years ago by Vivek2.3k
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