Question: Where Can I Find Mutation Databases Specialized In Cancer?
13
gravatar for Ahlam Ahmed
7.3 years ago by
Ahlam Ahmed140
tripoli
Ahlam Ahmed140 wrote:

I need mutated breast cancer genes for my analysis.  So I'm bit confused whether there is an existing database which consists of sequences having mutations in it. Is there any database to get the mutated & non-mutated gene sequence?

cancer mutation database • 17k views
ADD COMMENTlink modified 11 weeks ago by Sean Davis25k • written 7.3 years ago by Ahlam Ahmed140
20
gravatar for Malachi Griffith
4.3 years ago by
Washington University School of Medicine, St. Louis, USA
Malachi Griffith17k wrote:

Here are some related resources that are focused on somatic mutations in cancer:

DOCM - Database of Curated Mutations

CIViC - Clinical Interpretation of Variants in Cancer

BioStars post: CIViC - Clinical Interpretation of Variants in Cancer

Here is another generally relevant post: Database Of Tumor Suppressors And/Or Oncogenes

ADD COMMENTlink modified 11 weeks ago by RamRS22k • written 4.3 years ago by Malachi Griffith17k
8
gravatar for Sean Davis
7.3 years ago by
Sean Davis25k
National Institutes of Health, Bethesda, MD
Sean Davis25k wrote:

I'd suggest starting with COSMIC and ICGC.

ADD COMMENTlink modified 11 weeks ago by RamRS22k • written 7.3 years ago by Sean Davis25k

Thank you SEAN but, it doesn't contain information for many other genes like BRCA1 & BRCA2

ADD REPLYlink modified 4.3 years ago by Malachi Griffith17k • written 7.3 years ago by Ahlam Ahmed140

The databases I noted above are about somatic mutation, not germline mutation. Were you looking for somatic mutation databases or germline variants?

ADD REPLYlink written 7.3 years ago by Sean Davis25k

Dear sean i'm looking for Ashkenazi mutations database ,187_189delAG and 5382insC in BRCA1and 6174delT in BRCA2.

ADD REPLYlink written 7.3 years ago by Ahlam Ahmed140

Hi Sean, Does COSMIC have the information about somatic mutation ? Can you please point to the URL. I only found information at the gene level (cancer consensus genes). Thank you !!

PS: The link is here: http://cancer.sanger.ac.uk/cosmic/download

ADD REPLYlink modified 3.2 years ago • written 3.2 years ago by Chirag Nepal2.2k
5
gravatar for raunakms
7.3 years ago by
raunakms1.1k
Vancouver, BC, Canada
raunakms1.1k wrote:

Here are few such databases:

ADD COMMENTlink modified 11 weeks ago by RamRS22k • written 7.3 years ago by raunakms1.1k

thnks RAUNAK,but i did n't find any database about ,187_189delAG and 5382insC in BRCA1and 6174delT in BRCA2.

ADD REPLYlink written 7.2 years ago by Ahlam Ahmed0
0
gravatar for sue.mockus
2.9 years ago by
sue.mockus0
sue.mockus0 wrote:

Newly released: jax.org/ckb

ADD COMMENTlink written 2.9 years ago by sue.mockus0
0
gravatar for Sean Davis
11 weeks ago by
Sean Davis25k
National Institutes of Health, Bethesda, MD
Sean Davis25k wrote:

Perhaps not a direct answer, but take a look at:

https://github.com/seandavi/awesome-cancer-variant-databases

ADD COMMENTlink written 11 weeks ago by Sean Davis25k
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