I need mutated breast cancer genes for my analysis. So I'm bit confused whether there is an existing database which consists of sequences having mutations in it. Is there any database to get the mutated & non-mutated gene sequence?
Here are some related resources that are focused on somatic mutations in cancer:
BioStars post: CIViC - Clinical Interpretation of Variants in Cancer
BioStars post: Exploring cancer mutation data portals
Here is another generally relevant post: Database Of Tumor Suppressors And/Or Oncogenes
Here are few such databases:
- Sanger: Cancer Gene Census
- Sanger: COSMIC
- Somatic Mutations in Epidermal Growth Factor Receptor DataBase
- IARC TP53 Database
- Breast Cancer Information Core - An on-line breast cancer mutation database. This is an international collaboration hosted by the NIH National Human Genome Research Institute. The Web site includes the database (requires registration), laboratory methods, forum and resources.
Perhaps not a direct answer, but take a look at: