Target Genes Of E2F
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9.3 years ago
Plasmid ▴ 160

I am searching E2F target genes in human. E2F family has 8 proteins E2F1-8. I am interested all of them. Until now I searched for tons of literature to find a complete list of E2F target genes. The problem is the list is not complete. Every day I found each new gene which is controlled by E2F. Is there any database where can I find complete updated list of E2F target genes? Thank You

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Curse those biologists for continually generating new data :) Also - which organism?

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Seemingly E2F is a family of TFs, not a single one, that might explain the multitude of targets. If you could focus your study on a specific factor, that might help your progress. Otherwise, what was asked before about TF-(BS) databases applies here too: http://biostar.stackexchange.com/questions/6507/best-database-of-transcription-factor-binding-sites

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9.3 years ago
David L. ▴ 110

The following databases contain E2F target genes:

  • E2F transcription factor network (NCBI/biosystems)
  • Transcription Factor Encyclopedia (E2F1-7, includes TFBS from JASPAR and targets from PAZAR)
  • Transcriptional Regulatory Element Database (TRED, E2F1-7)
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I used first two database but the number of target gene is far lower than those I've collected by literature search. But I got a large list of protein from last database. I am now controlling each of Target genes. Thank you very much.

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