Question: Gene network and homology help. Can I assume that genes found in mice act similar to the same genes found in humans?
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gravatar for humzahmahm
3.0 years ago by
humzahmahm0
humzahmahm0 wrote:

I am an undergrad student in an intro to Bioinformatics course, and I am currently doing an independent project to explore different methods of analysis.

In particular, in a paper I am currently reading, it states that there are 4 proteins that have been found to interact together and prevent a disease in mice.

If these genes are also found in humans, can I assume that these genes will have a similar network function in a human model?

homology network genemania • 810 views
ADD COMMENTlink modified 3.0 years ago by Jean-Karim Heriche18k • written 3.0 years ago by humzahmahm0
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gravatar for genomax
3.0 years ago by
genomax65k
United States
genomax65k wrote:

A comprehensive list of human/mouse homologs is available from MGI at Jackson labs. This class report file is also useful.

ADD COMMENTlink modified 3.0 years ago • written 3.0 years ago by genomax65k

This is great, I found the genes I was looking for. Thank you

ADD REPLYlink written 3.0 years ago by humzahmahm0
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gravatar for Jean-Karim Heriche
3.0 years ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche18k wrote:

It depends on what you mean by network function. I think it's quite reasonable to assume that orthologs are involved in the same biological process. In many cases, it can be shown that a human gene can rescue the loss of function phenotype of a mouse ortholog and vice versa.

Edit: corrected typo

ADD COMMENTlink modified 3.0 years ago • written 3.0 years ago by Jean-Karim Heriche18k
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gravatar for Chris Miller
3.0 years ago by
Chris Miller20k
Washington University in St. Louis, MO
Chris Miller20k wrote:

Nope! You can cite it as evidence that they may play similar roles in human, but you should always proceed cautiously, even when moving between closely related mammalian species.

ADD COMMENTlink written 3.0 years ago by Chris Miller20k

Thank you so much for your response!

ADD REPLYlink written 3.0 years ago by humzahmahm0
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