How to tell bloodtype from SNPs data?
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5.0 years ago
O.rka ▴ 300

I want to check my bloodtype based on my SNPs data. I have results from AncestryDNA with ~ 668 943 SNPs. Is there a website I can go to to import the data and get this phenotype?

Format of my data:

rsid    chromosome  position    allele1 allele2
rs369202065 1   569388  G   G


Each line corresponds to a SNP. Column one provides the SNP identifier (rsID where possible). Columns two and three contain the chromosome and basepair position of the SNP using human reference build 37.1 coordinates. Columns four and five contain the two alleles observed at this SNP (genotype). The genotype is reported on the forward (+) strand with respect to the human reference.

SNP genome human analyze ancestry • 15k views
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Are you looking for a quick look-up or a lifelong career? Because you're looking for a genotype-phenotype correlation that I'm not sure exists yet.

EDIT: From genomax's link, it looks like there is quite a bit known on this topic. If the data is reliable depends on your purpose though, if you ask me.

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It is difficult to find authoritative information on ABO. For basic bio background, I found this review very helpful.

Yip, S. P. (2002). Sequence variation at the human ABO locus. Annals of human genetics, 66(1), 1-27.

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5.0 years ago
matted 7.5k

Promethease should work for this. They have an example report from Ancestry.com data that includes a blood type prediction (click the "Blood" tab).

There are many related web tools in this space; see http://www.23andyou.com/3rdparty for one list.