The mutation which occurs in sickle-cell anaemia is a good example of Mendelian disease. From books , from wikipedia and many genetics documentation, you will read :
The sickle-cell disease occurs when the sixth amino acid, glutamic acid, is replaced by valine to change its structure and function; as such, sickle-cell anemia is also known as E6V
So I checked myself from UCSC genom browser , which show it's E7V !
I also search from clinvar which confirm the genom browser :
So my question.... Am I wrong ? Or all books are wrong ?