I have to do a comparison of two groups. The first group has 1 sample and the second group has 2 samples. What is the most appropriate statistical test/software for this comparison? The resources that are most readily available to me are:
- Baggerly's test (test on proportions
- Edge (Edge R basically)
- I have a Gaussian model but I have never tried it out before.
I know 1 vs 2 is not ideal, but it's the challenge I've been given. I reason that DeSeq2 needs ideally 3 replicates per group and 2 replicates per group is pushing it. Not sure which of the rest is most appropriate.
Help would be very much appreciated. Thanks!