I have a group of genes associated with one disease (disease-genes) and a group of drugs used to treat the same disease (disease-drugs). I'm wondering if there's a way to test if the "disease-drugs" are targeting significantly these genes more than any other genes. I was thinking to evaluate the null hypothesis with a Fisher test in a table like this:
disease-genes | non-disease genes disease-drugs 30 211 non-disease drugs 80 1006
However, I noticed that some drugs non-associated with the disease are also targeting the same genes that the "disease-drugs", which implies that the "disease-genes" are not exclusive to only one category. Can I use the Fisher test even with this overlap? or there's any way to test this association?