Question: Ancestry Informative Markers
gravatar for Inquisitive8995
7 weeks ago by
Inquisitive899510 wrote:

Hi, How do I find the Ancestry Informative Makers in the 1000 Genomes Project data. Is there a tool to identify the AIMs in all the given populations? Any help would be appreciated. Thanks in Advance.

ADD COMMENTlink modified 6 weeks ago by Kevin Blighe9.0k • written 7 weeks ago by Inquisitive899510
gravatar for Kevin Blighe
6 weeks ago by
Kevin Blighe9.0k
Kevin Blighe9.0k wrote:


Yes, I have built my own predictive model based on the 1000 Genomes Data - it has 99% sensitivity/specificity.

Take a look at my tutorial here: Produce PCA for 1000 Genomes Phase III in VCF format

If you get through that, it would be a great start toward building your own model.


ADD COMMENTlink written 6 weeks ago by Kevin Blighe9.0k

Hi Kevin, Sorry about the delay in responding. Thanks for your reply. I understand from your link that you are using PCA to create the model. I don't exactly get the point where AIMs can be obtained from the process. It would be really helpful if you could explain it to me a little. Thanks in Advance.

ADD REPLYlink written 24 days ago by Inquisitive899510

The PCA bi-plot will have been based on markers that segregate the different 1000 Genome populations. So, you then take these markers and test them through regression modelling to see which ones are the best at segregating each group. At the end of the day, weather forecasting, predicting the stock markets, predicting ethnicity, et cetera are all based on modelling and then predicting.

ADD REPLYlink written 24 days ago by Kevin Blighe9.0k

Okay. Got it ! Thanks a lot

ADD REPLYlink written 21 days ago by Inquisitive899510
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