Question: Structure of an enzyme
gravatar for Natasha
17 months ago by
Natasha30 wrote:

Hi All,

I am looking for information about the structure of an enzyme in a given tissue.

For example, The enzyme Phosphosfructokinase exists in three forms. PFKM,PFKL,PFKP The structure of the enzyme is different in different tissues. i.e" in Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3."(uniprot)

I want to know the form in which it is expressed in pancreas. I am trying to find the tissue specific structure of many such enzymes.Is there any database where I can look for this information?

Many thanks,


ADD COMMENTlink modified 17 months ago • written 17 months ago by Natasha30

As mentioned in one of the answers, PDB is the repository for resolved structures. You may be able to use Uniprot or PDB to find related structures to any given PDB (though I don’t have specific info on how). It the same protein has been resolved in several forms, I would expect them to be linked somehow.

ADD REPLYlink written 17 months ago by jrj.healey12k
gravatar for Antonio R. Franco
17 months ago by
Spain. Universidad de Córdoba
Antonio R. Franco4.0k wrote:

The only protein 3D database I am aware of is PDB

ADD COMMENTlink written 17 months ago by Antonio R. Franco4.0k

Thanks to both of you for the advice.The protein stoichiometry of PFK- phosphofructokinase in muscle is gives as Homo-2-mer.Whereas in uniprot it is mentioned PFK exists as a tetramer and M4 is the active form in muscle.

I am a little confused.Is the protein structure a Homo-2mer or a tetramer?

ADD REPLYlink written 17 months ago by Natasha30

Biological units.

ADD REPLYlink written 17 months ago by genomax67k
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