Need to know the importance of prediction
1
0
Entering edit mode
3.8 years ago

Hello team,

We always study the importance of structure prediction and simulation method. Prediction of protein folding from its amino acid sequence and to refine the model using Newton's equation. If this is so important, why predicted model could not submit in PDB or any other pioneer database. I hope this time I will get the answer.

Thanks and regards, Sakshi

structure prediction MD simulation • 974 views
ADD COMMENT
1
Entering edit mode
3.8 years ago
Joe 19k

Without experimental validation, the models could be wrong. Even if the structures appear accurate from, for example, threading approaches, the final model will lack any post-translational modifications which would be seen if it were solved experimentally. In order to keep the databases free of spurious information, you cannot submit any old simulation that you like. Long term it would probably harm subsequent analyses by others, leading them to false homologies etc.

ADD COMMENT
0
Entering edit mode

Thanks for the information.

ADD REPLY

Login before adding your answer.

Traffic: 1503 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6