Question: Need to know the importance of prediction
gravatar for sakshisingh.bioinfo
22 months ago by
sakshisingh.bioinfo30 wrote:

Hello team,

We always study the importance of structure prediction and simulation method. Prediction of protein folding from its amino acid sequence and to refine the model using Newton's equation. If this is so important, why predicted model could not submit in PDB or any other pioneer database. I hope this time I will get the answer.

Thanks and regards, Sakshi

ADD COMMENTlink modified 22 months ago by WouterDeCoster42k • written 22 months ago by sakshisingh.bioinfo30
gravatar for Joe
22 months ago by
United Kingdom
Joe15k wrote:

Without experimental validation, the models could be wrong. Even if the structures appear accurate from, for example, threading approaches, the final model will lack any post-translational modifications which would be seen if it were solved experimentally. In order to keep the databases free of spurious information, you cannot submit any old simulation that you like. Long term it would probably harm subsequent analyses by others, leading them to false homologies etc.

ADD COMMENTlink written 22 months ago by Joe15k

Thanks for the information.

ADD REPLYlink written 22 months ago by sakshisingh.bioinfo30
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1360 users visited in the last hour