Question: Need to know the importance of prediction
0
gravatar for sakshisingh.bioinfo
13 months ago by
India/Varanasi/BHU
sakshisingh.bioinfo30 wrote:

Hello team,

We always study the importance of structure prediction and simulation method. Prediction of protein folding from its amino acid sequence and to refine the model using Newton's equation. If this is so important, why predicted model could not submit in PDB or any other pioneer database. I hope this time I will get the answer.

Thanks and regards, Sakshi

ADD COMMENTlink modified 13 months ago by WouterDeCoster38k • written 13 months ago by sakshisingh.bioinfo30
1
gravatar for jrj.healey
13 months ago by
jrj.healey11k
United Kingdom
jrj.healey11k wrote:

Without experimental validation, the models could be wrong. Even if the structures appear accurate from, for example, threading approaches, the final model will lack any post-translational modifications which would be seen if it were solved experimentally. In order to keep the databases free of spurious information, you cannot submit any old simulation that you like. Long term it would probably harm subsequent analyses by others, leading them to false homologies etc.

ADD COMMENTlink written 13 months ago by jrj.healey11k

Thanks for the information.

ADD REPLYlink written 13 months ago by sakshisingh.bioinfo30
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