I am asked to conduct a GWAS and to have some novelty in the study too. 1200 cases have a cardiovascular disease and 1800 controls have other types of diseases (such as diabetes, cancers, etc.). Hundereds of thousands of SNPs have been genotyped. What can be considered as novelty when GWAS can only examine the association between genetic variants (such as SNPs or CNVs) and a trait (here it is cardiovascular disease)? There are many studies conducted on this subject and I don't know what more can someone do to be considered novel. They tell me to read recent articles but I don't know what to look for more than applying the current tools on the data such as plink. I am a biostatistician, by the way, and I guess that is up to them (they are geneticists) to bring novelty not me because my job as a biostatistician is just to find a statistical method to solve a question not to find a question on behalf of them. Would Someone please give me a hint?
Thanks a lot