What is CINWntUp and CINnormL?

Question

[louis-gil]

What is CINWntUp and CINnormL?

I read a paper that uses this two things as classes but Im not sure what they represent. I imply that CIN is referring to Chromosomal instability but I don't know what WntUp & normL refer to. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214593/)

[WouterDeCoster]

Hello louis-gil!

It appears that your post has been cross-posted to another site: https://biology.stackexchange.com/questions/78814/question-what-is-cinwntup-and-cinnorml

This is typically not recommended as it runs the risk of annoying people in both communities.

[WouterDeCoster]

I read a paper

Don't you think it would be useful to link us to that paper?

[louis-gil]

Thanks, I forgot to add the link.

Answer 1

[Kevin Blighe]

Yes, CIN is chromosomal instability.

CINWntUp, in this context, relates to CIN in colon cancer samples in which the Wnt pathway is up-regulated. CINnormL relates to CIN in colon cancer samples that have a 'normal-like' expression profile.

Further details:

• https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE39582
• https://www.ncbi.nlm.nih.gov/pubmed/23700391

Kevin