I've got a series of data for a certain tissue, a type of cancer). We suspect that when tissues were sampled (biopsy/surgery) we end up with a mixture of different tissues, so when we do the analysis, it is not just the target tissue + tumour cells, it will also have a significant proportion of fibroblasts swiped along. Surgeries are supposed to err on the safe side after all.
How do I approach this from the analysis point of view? For starters, I would like to know, based on the expression profiles of my samples, how big is the fibroblast component?