I am doing miRNA differential expression analysis from the Read counts, but I have few questions: 1. Which one is better DEseq2 and EdgeR 2. I have total 452 samples with 4 condition and each condition have different sample no. How to analyze this type of data. 3. I want to check the expression of miRNAs for the individual condition, I mean which miRNAs are Down or UP-regulated in which condition.
Please help me in this regard.