I'm hoping for some help on drug clustering by gene list. The data I have has not come through any particular workflow, it's all held in text files.
I have a 100 drugs and per drug I have a list up/down genes. Whether a gene is up/down regulated is purely by its presence in a text file (as two columns, "up" and "down"). There is no numerical expression data at all.
I have very little clustering experience. I was hoping to learn whether it would be possible cluster among the 100 drugs by their up/down gene lists similarity. As for a clustering cut-off, I'm not entirely sure and I am happy for that to be exploratory for the time being providing it finds some separation.
Anything available in R would be very helpful.