I am aware of that multiple testing correction is needed when multiple hypothesis tests are simultaneously performed. However, I am a little confused by the word "simultaneously".
Say I have called somatic variants from hundreds of samples. With this sample-variant matrix, I would like to perform pairwise fisher exact test for variant co-occurrence. Do I need to carry out multiple testing correction on the P-value of each paired variants?
I guess multiple testing correction is needed. However, I can consider that each of the pairwise fisher exact test was carried out individually and each raw p-value represents the significance of correponding paired variants, right?